If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Our dosage calculator can help you with this as well. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Deferasirox chelates iron. Applies only to oral form of both agents. UpToDate. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Applies only to oral form of both agents. Deferoxamine chelates iron. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Venofer treatment may be repeated if necessary. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. We'll do this entirely for free, as long as the calculator has applications for women's health. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . It is unlikely . Accessed: 4/12/2011. Use Caution/Monitor. Applies only to oral form of both agents. Avoid or Use Alternate Drug. This site complies with the HONcode standard for trust- worthy health information: verify here. 2015: 763576. The primary endpoint was the proportion of patients with . Use Caution/Monitor. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Where C= concentration of The recipient will receive more details and instructions to access this offer. Learn how to store and discard medical supplies safely. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Ferritin and transferrin are also recommended monitoring . Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. All Rights Reserved. Use Caution/Monitor. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Venofer treatment may be repeated if necessary. Kidney Int. Venofer must only be administered intravenously either by slow injection or by infusion. 1990 Feb;24(2):162-6. Can't find what you need? Applies only to oral form of both agents. If we don't have the calculator you need we'll try to make it for you and add it to the website. Information last revised December 2022. LBW = Lean body weight in kg. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. 1996 Aug;11(4):139-46. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Use Caution/Monitor. ]Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. Fulminant symptoms include confusion, sensation of passing out, paleness. . prescription products. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. You may report side effects to Health Canada at 1-866-234-2345. Use Caution/Monitor. Separate by 2 hr. 1982;13(4):309-21. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Always ask your health care professional for complete information about this product and your specific health needs. David McAuley, Pharm.D. Last updated 28/06/2018 Enter values here and press 'Calculate'. Consult your pharmacist or local waste disposal company. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. Methods. Minor/Significance Unknown. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Although the original formula requires the weight in kilograms, values input in lbs are transformed. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Applies only to oral form of both agents. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Applies only to oral form of both agents. If either is present, do not use the liquid. Either increases effects of the other by pharmacodynamic synergism. These can be input in g/dL, g/L or mmol/L. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Applies only to oral form of both agents. Minor/Significance Unknown. Venofer may reduce the absorption of concomitantly administered oral iron preparations. . Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Use Caution/Monitor. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. 1 ,*. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Med J Aust; 193(9):525-32. https://www.uptodate.com/ (Requires subscription). Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. May increase risk of hypotension. Use Caution/Monitor. Anemia; 2015: 763576. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Applies only to oral form of both agents. Dosage form: injection, solution Slowing the infusion rate may alleviate symptoms. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Pregnancy: Risk Summary-Clinical Considerations. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. There are physiological variation in iron reserves such as the decrease during menstruation period. Applies only to oral form of both agents. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Avoid or Use Alternate Drug. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. Applies only to oral form of both agents. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. It can be expressed in mg per ml. Applies only to oral form of both agents. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . You can further save the PDF or print it. 2000 Jan;22(1):39-43. commonly, these are "preferred" (on formulary) brand drugs. Patients measured hemoglobin can be input in g/dL or mmol/L. Minor/Significance Unknown. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Use Caution/Monitor. Schweiz Med Wochenschr. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. commonly, these are "non-preferred" brand drugs. Applies only to oral form of both agents. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Do not double the dose to catch up. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Due Date form Ultrasound Report. Official Journal of the International Society of Nephrology. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Copyright 2021 GlobalRPH - Web Development by. Objective. Applies only to oral form of both agents. Dosing: (a) Divide calculated total cumulate dose . If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Contraindicated. Minor/Significance Unknown. Do not administer Venofer to patients with iron overload. official version of the modified score here. ANNA J. Use Caution/Monitor. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Iron sucrose: 20 mg/mL. Minor/Significance Unknown. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Use Caution/Monitor. restrictions. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Use alternatives if available. iron sucrose increases levels of calcium chloride by enhancing GI absorption. J Med. Use Caution/Monitor. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. We comply with the HONcode standard for trustworthy health information. Human studies not conducted. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Applies only to oral form of both agents. Applies only to oral form of both agents. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Use Caution/Monitor. . 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